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Primary Duties
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The Senior Scientist will be part of the Pre-Clinical Bioanalytics (PCB) group, supporting multiple fast-paced non-clinical studies for advancing novel gene therapy programs across all Therapeutic Areas. The position requires strong scientific and technical skills in method development and sample testing with a focus on molecular assays.
- Apply strong molecular biology and bioanalytical knowledge for developing nucleic acid-based bioassays to support the preclinical activities.
- Utilize high level of technical expertise and sound judgment for troubleshooting complex molecular biology technical problems and finding appropriate solutions.
- Expertise in DNA, RNA, and miRNA assays, including nucleic acid isolation from various tissue types.
- Proficient with RT/ qPCR methods and modern molecular biology tools such as digital PCR for highly sensitive applications, including gene copy number.
- Comfortable with high-throughput processing devices such as QuantStudio, QIASymphony and KingFisher to accommodate large number of sample testing.
- Independently perform experiments and analyze data to support PCB workflow and meet strict timelines.
- Prepare technical documentations as required.
- Mentor junior team members as appropriate.
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Responsibilities
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% of Time
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Job Function and Description
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70%
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- Hands-on laboratory work, plan and perform experiments, analyze data, and record experiments using good documentation practices.
- Technical troubleshooting and finding suitable resolutions.
- Mentor junior team members.
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20%
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- Participate in group discussions, advance molecular bioassay capability and support PCB workflow.
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10%
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- Stay current with all required lab safety and compliance training.
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Education and Experience Requirements
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- M.S./ Ph.D. in a relevant field required.
- 3 to 5+ years laboratory experience with a focus on molecular assays.
- Experience in research, CRO and/ or industry environment.
- Extensive experience using analytical tools such as QuantStudio, Prism and Excel.
- Experience with bioassays and testing of biological samples.
- Knowledge of regulatory requirements for GLP assays is a plus.
- Experience with gene therapy is a plus.
- Experience with basic research is a plus.
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Key Skills, Abilities, and Competencies
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- Excellent organizational and multi-tasking skills are required.
- Excellent interpersonal, writing, and verbal communication skills are required.
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