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Senior Scientist

Date: Jun 5, 2022

Location: Philadelphia, PA, US, 19104

Company: Spark Therapeutics

Join the Spark Team


We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.


We don’t follow footsteps. We create the path.

The Senior Scientist will be part of the Pre-Clinical Bioanalytic (PCB) group, supporting multiple fast-paced non-clinical studies for advancing novel gene therapy programs across all Therapeutic Areas. The position requires strong scientific and technical skills in bioanalytical method development and preclinical sample analysis with a focus on immunoassays. 

•            Apply scientific and bioanalytical knowledge for developing method for various immunoassays such as biomarker, anti-drug antibody, cell-based neutralizing antibody (NAb) assay, and enzymatic activity assays to support the preclinical activities.

•            Utilize high level of technical expertise and sound judgment for troubleshooting complex technical problems and finding appropriate solutions.

•            Independently perform experiments and data analysis to support PCB workflow for bioanalytical assay development and preclinical sample testing to meet strict timelines.

•            Experience with and/or ability to develop bioassays using various platforms such as ELISA, MSD-ECL, Gyrolab, and ProteinSimple Wes/ Jess.

•            Prepare technical documentations as required.

•            Mentor junior team members as appropriate.



  • Hands-on laboratory work, plan and perform experiments, analyze data, and record experiments using good documentation practices.
  • Technical troubleshooting and finding suitable resolutions.
  • Mentor junior team members.
  • Participate in group discussions, advance bioassay capability and support PCB workflow.
  • Stay current with all required lab safety and compliance training.


Education and Experience Requirements

•            M.S./ Ph.D. in a relevant field required.

•            3 to 5+ years laboratory experience in immunoassays.

•            Experience in research, CRO and/ or industry environment.

•            Extensive experience with bioassays and testing of biological samples.

•            Extensive experience using analytical tools such as SoftMax Pro, Gen5, and Prism.

•            Knowledge of regulatory requirements for GLP assays a plus.

•            Experience with gene therapy a plus.

•            Experience with liquid handler and/ or automation a plus.

•            Experience with basic research a plus.


Key Skills, Abilities, and Competencies

•            Excellent organizational and multi-tasking skills are required.

•            Excellent interpersonal, writing, and verbal communication skills are required.


Complexity and Problem Solving

•            Self-motivated, flexible, and willing to adapt to shifting priorities.

•            Keen attention to detail and the ability to meet deadlines.

•            Inter and Intra-team collaborations to support gene therapy programs.

•            Must be comfortable in the fast-paced work environment and interact with multi-disciplinary research teams.

•            Champion all safety aspects in the laboratories.


Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location.  Accommodations may be made in accordance with applicable law.

Nearest Major Market: Philadelphia