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Senior Scientist- Immunology

Date: Jan 10, 2019

Location: Philadelphia, PA, US

Company: Spark Therapeutics

Join the Spark Team

 

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.

 

We don’t follow footsteps. We create the path.

Summary

The Immunologist will:

• With guidance and supervision from the group leader or supervisor, conduct R&D experiments related to immune responses in gene therapy.

• Perform clinical and preclinical sample analysis per SOPs and generate data with high scientific quality to meet GLP regulatory expectations.

• Participate in development and validation of bioanalytical assays such as immunoassays and cell-based assays.

• Implement new assays or optimize existing assays based on in-depth knowledge of laboratory techniques.

• Participate in sample management activities such as receiving, processing, storage and shipping clinical and preclinical samples.

• Participate in instrument maintenance and qualification. 

• Maintain accurate, timely and detailed records of work.

Responsibilities

55%

Perform R&D experiments related to immune responses in gene therapy

10%

Analyze clinical samples per existing SOPs

10%

SOP and technical report writing

10% Immune assay development and validation

5%

Sample management

5%

Instrument maintenance/qualification

5%

Reagent inventory, ordering, preparation and qualification

Qualifications

• Hands-on experience performing immunoassays such as MSD platform, flow cytometry, ELISA, ELISPOT, neutralizing antibody assay etc.

• Scientific background in AAV gene therapies is a plus

• Experience with studies in laboratory animal models

• Understanding of GLP principals is a plus

• Strong publication record is a plus.

• Ability to work independently after initial training as well as being part of a team; possess self-motivation, adaptability, and a positive attitude

• Excellent organizational, communication and collaborations skills

Requirements

  • PhD in Immunology (preferred) or a scientific discipline, 3-5 years of related experience.
  • Hands-on experience performing immunoassays such as MSD platform, flow cytometry, ELISA, ELISPOT, neutralizing antibody assay etc.
  • Scientific background in AAV gene therapies is a plus
  • Experience with studies in laboratory animal models
  • Understanding of GLP principals is a plus
  • Strong publication record is a plus.
  • Ability to work independently after initial training as well as being part of a team; possess self-motivation, adaptability, and a positive attitude
  • Excellent organizational, communication and collaborations skills


Nearest Major Market: Philadelphia

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