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Senior Scientist- Immunologist

Date: Dec 4, 2018

Location: Philadelphia, PA, US

Company: Spark Therapeutics

Join the Spark Team

 

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.

 

We don’t follow footsteps. We create the path.

The Immunologist will:

  • With guidance and supervision from the group leader or supervisor, conduct R&D experiments related to immune responses in gene therapy.
  • Perform clinical and preclinical sample analysis per SOPs and generate data with high scientific quality to meet GLP regulatory expectations.
  • Participate in development and validation of bioanalytical assays such as immunoassays and cell-based assays.
  • Implement new assays or optimize existing assays based on in-depth knowledge of laboratory techniques.
  • Participate in sample management activities such as receiving, processing, storage and shipping clinical and preclinical samples.
  • Participate in instrument maintenance and qualification.
  • Maintain accurate, timely and detailed records of work.

Responsibilities

% of Time

Job Function and Description

55

Perform R&D experiments related to immune responses in gene therapy

10

Analyze clinical samples per existing SOPs

10

SOP and technical report writing

10

Immune assay development and validation

5

Sample management

5

Instrument maintenance/qualification

5

Reagent inventory, ordering, preparation and qualification

Education and Experience Requirements

PhD in Immunology (preferred) or a scientific discipline, 3-5 years of related experience.

Key Skills, Abilities, and Competencies

  • Hands-on experience performing immunoassays such as flow cytometry, ELISA, ELISPOT, neutralizing antibody assay etc.
  • Scientific background in AAV gene therapies is a plus
  • Experience with studies in laboratory animal models
  • Understanding of GLP principals is a plus
  • Strong publication record is a plus.
  • Ability to work independently after initial training as well as being part of a team; possess self-motivation, adaptability, and a positive attitude
  • Excellent organizational, communication and collaborations skills

 

Complexity and Problem Solving

  • Under supervision, develop solutions to a variety of problems of simple to moderate scope and complexity. Refers to policies and practices for guidance.
  • Under supervision, work on problems of simple to moderate scope where analysis of situations or data requires a review of a variety of factors.  Exercises judgment within defined procedures and practices to determine appropriate action.
  • Plans schedules and arranges own activities to accomplish objectives

Internal and External Contacts

Job is accountable to Immune Assay Lead and coordinates with all members of Immunology group.


Nearest Major Market: Philadelphia

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