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Scientist-Downstream Process Development

Date: Apr 22, 2021

Location: Philadelphia, PA, US

Company: Spark Therapeutics

Join the Spark Team


We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.


We don’t follow footsteps. We create the path.



The process development downstream team is seeking a highly motivated and innovative process scientist. The position will primarily a lab-based role, s/he is responsible for developing robust and scalable downstream manufacturing process to support early and late phase gene therapy products in Spark’s innovative pipeline. The role will also be responsible for providing technical support to technology transfer, scale up, and internal/external manufacturing, as well as regulatory filings as needed.



60% • Design and execute lab experiment to develop efficient, robust, scalable and cost-effective downstream purification process


25% • Analyze and interprets process and analytical data to make sound decisions • Maintain accurate and complete lab notebooks. Authoring technical reports, data summaries, tech transfer reports. • Present results in internal meetings or external conferences


15% • Interact with internal and external partners, may represent functional area on cross functional teams • Support downstream process tech transfer, scale-up, clinical and commercial manufacturing as needed • Support regulatory filings • Leverage personal strength, knowledge and experience to mentor colleagues or intern student



Ph.D. in Chemical/Biochemical Engineering, Biological Sciences, or a related scientific discipline, or MS with 3+ years of relevant industry experience



  • Strong organizational skills and detailed documentation abilities is required.
  • Work independently in hands-on laboratory setting, self-motivated to learn and develop new techniques
  • Perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies.
  • Excellent writing and verbal communication skills is required.
  • Teamwork a must.
  • Must be comfortable in the fast-paced, multi-tasking biotech environment

Nearest Major Market: Philadelphia