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Scientist (Pre-Clinical Bioanalytics)

Date: Jun 30, 2022

Location: Philadelphia, PA, US, 19104

Company: Spark Therapeutics

Join the Spark Team


We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.


We don’t follow footsteps. We create the path.

Scientist PCB


Primary Duties

The Scientist will be part of the Pre-Clinical Bioanalytics (PCB) group, supporting multiple fast-paced non-clinical studies for advancing novel gene therapy programs across all Therapeutic Areas. The position requires strong scientific and technical skills in bioanalytical method development and preclinical sample analysis with a focus on immunoassays.  

  • Apply scientific and bioanalytical knowledge for developing method for various immunoassays such as biomarker, anti-drug antibody, cell-based neutralizing antibody (NAb) assay, and enzymatic activity assays to support the preclinical activities.
  • Utilize high level of technical expertise and sound judgment for troubleshooting complex technical problems and finding appropriate solutions.
  • Independently perform experiments and data analysis to support PCB workflow for bioanalytical assay development and preclinical sample testing to meet strict timelines.
  • Experience with and/or ability to develop bioassays using various platforms such as ELISA, MSD-ECL, SIMOA, Gyrolab, and ProteinSimple Wes/ Jess.
  • Prepare technical documentations as required.
  • Mentor junior team members as appropriate.



  • Hands-on laboratory work, plan and perform experiments, analyze data, and record experiments using good documentation practices.
  • Technical troubleshooting and finding suitable resolutions.
  • Mentor junior team members.


Education and Experience Requirements

Key Skills, Abilities, and Competencies

Complexity and Problem Solving

  • Self-motivated, flexible, and willing to adapt to shifting priorities.
  • Keen attention to detail and the ability to meet deadlines.
  • Inter and Intra-team collaborations to support gene therapy programs.
  • Must be comfortable in the fast-paced work environment and interact with multi-disciplinary research teams.
  • Champion all safety aspects in the laboratories.

Internal and External Contacts

Therapeutic Areas and Research teams, Bioanalytics and Lab management teams, and Quality Assurance.

Other Job Requirements

Up to 5% Travel may be required.


Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location.  Accommodations may be made in accordance with applicable law.

Nearest Major Market: Philadelphia