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Program Manager Lead

Date: Jun 3, 2021

Location: Philadelphia, PA, US

Company: Spark Therapeutics

Join the Spark Team


We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.


We don’t follow footsteps. We create the path.




The Program Management (PM) Lead will be primarily responsible for managing the cross-functional activities of one or more Asset Teams and will be responsible for the integration of strategy into an Integrated Program Plan (IPP).   The PM Lead will support the Asset Team General Manager (AGM) and the Asset Team.  He/She will contribute a strategic perspective and will identify risks and challenges to be addressed, track progress versus the plan, facilitate informed and timely decision making for a program, communicate program milestones to stakeholders, and facilitate governance interactions for stage gate transitions and any significant changes to the IPP.  In some cases, the PM Lead may run the Asset Team meeting in the absence of the AGM.


The incumbent will be responsible for the program management of at least 1 Asset Team and/or 1 or more Candidate Development Teams (CDTs), manage business initiatives, and support the development and implementation of a Program Management Center of Excellence (including an enterprise software planning system and milestone reports).  The PM Lead will excel in operations and is a problem solver with proficiency in project management and ideally has experience managing development programs (IND-> Commercialization).





Asset Team Program Management (depending on stage of program the % of time will vary):

Creates and regularly maintains the IPP (based on collective inputs of functional project managers and the team representatives) Ensures that plans are aligned with strategic objectives for the program

Schedules Asset Team meetings and works with the Asset GM to agree on meeting agenda and ensures it is appropriate for the meeting

Works closely with the AGM in ensuring key activities, milestones and functional inputs are integrated

Works with team members and sub-teams to develop scenarios for evaluation and resolve issues

Facilitates annual budgeting and strategic planning for the Program; maintains the program budget

Updates the IPP / Gantt chart based upon updates and events using enterprise planning techniques and software

Records meeting discussions, activities, action items and decisions

Creates status updates and dashboards to be reviewed by the AGM and the Asset Team and circulated to Leadership

Supports team in the preparation for internal Spark governance such as stage gates

Collaborates closely with Alliance Management Lead on any partnered program


Develops other tools as needed to enhance transparent communications amongst the team and with governance bodies

Depending on allocation of time towards Asset Team:

Program manage 1 or more Candidate Development Teams (CDTs)

Work with CDT Leader to develop agendas, facilitate meetings and planning sessions, capture and follow-up on actions

Update early portfolio dashboards with program milestones

Prepare documentation regarding current results and forward-looking plans towards the achievement of stage gates

Provide program management support to business initiatives (e.g., change initiatives, or rollout of new processes)

Contribute to the development and testing of project management tools and processes to help establish a Program Management Center of Excellence within Spark

This may include:

Developing templates and tools for Asset Teams, CDTs, etc.

Adopting new technologies to better support functions

Providing expertise in MS Project, Project Server, OnePager, and Sharepoint

Providing training to functional project management teams

Providing a consistent look and feel across all templates and tools to ensure portability across teams


Educational and Experience Requirements


  • College degree in relevant field of study (required), graduate degree (preferred)
  • 10 years of experience in life sciences and biotechnology/pharmaceutical industry (required), with experience in managing cross-functional Development or Commercialization teams
  • 5 years of experience in life sciences and biotechnology industry asset-level project management with demonstrated knowledge of Project Management tools (e.g., MS Project)
  • Formal Project Management training (e.g., Project Management Professional) preferred
  • Proven ability to translate strategy and ensure tactical execution of solutions to operational issues in a fast-paced environment
  • Experience having successfully managed projects/programs and business/change initiatives
  • Demonstrated experience in scenario planning, problem resolution and goal setting for teams
  • Demonstrated track record of working collaboratively in a cross functional environment, and leading people without reporting authority
  • Distinctive communication (oral, written, and presentation), analytical, and strategic thinking skills
  • Limited Domestic and International Travel Required 
  • Exclellent planning, project management and problem-solving skills
  • Proven skills and negotiating solutions in complex enviornements



Nearest Major Market: Philadelphia