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Therapeutic Program Management Lead

Date: Apr 13, 2021

Location: Philadelphia, PA, US

Company: Spark Therapeutics

Join the Spark Team


We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.


We don’t follow footsteps. We create the path.


The Therapeutic Program Management (PM) Lead will be primarily responsible for managing the cross-functional activities of an Asset Team and will be responsible for the integration of strategy into the Integrated Program Plan (IPP).   The PM will support the Asset Team General Manager (GM) and the Asset Team.  He/She can contribute a strategic perspective and can identify risks and challenges to be addressed, track progress versus the plan and facilitate informed and timely decision making for a program.  In some cases, the PM can run the Asset Team meeting in the absence of the GM.


The incumbent will be responsible for the program management of at least 1 Asset Team and/or 1 or more Candidate Development Teams (CDTs), program manage business initiatives, and/or support the development and implementation of a Program Management Center of Excellence.   The ideal candidate excels in operations and is a problem solver with proficiency in project management and ideally has experience managing development programs (IND-> Commercialization).




50-70% Asset Team Program Management (depending on stage of program the % of time will vary):


  • Create and regularly maintains the IPP (based on collective inputs of functional project managers and the team).  Ensures that plans are aligned with strategic objectives for the Program.
  • Schedules Asset Team meetings and works with the Asset GM to agree meeting agenda and ensures it is appropriate for the meeting
  • Works closely with the GM in ensuring key activities, milestones and functional inputs are integrated
  • Works with team members and sub-teams to develop scenarios for evaluation and resolve issues
  • Facilitates annual budgeting and strategic planning for the Program; maintains the program budget
  • Updates the IPP / Gantt chart based upon updates and events
  • Records meeting discussions, activities, and agreements
  • Creates status updates and dashboards to be reviewed by the GM and the Asset Team and circulated to Leadership
  • Supports team in the preparation for internal Spark processes such as stage gates
  • Develops other tools as needed to enhance transparent communications amongst the team and with governance bodies.


30-50% Depending on allocation of time towards Asset Team:


  • Program manage 1 or more Candidate Development Teams (CDTs)


    • Work with CDT Leader to develop agendas, facilitate meetings and planning sessions, capture and follow-up on actions
    • Update early portfolio dashboards with program milestones
    • Prepare documentation towards the achievement of stage gates
    • Provide program management support to business initiatives (e.g. change initiatives, or rollout of new processes)


  • Contribute to the development and testing of project management tools and processes to help establish a Program Management Center of Excellence within Spark.  This may include:


    • Developing templates and tools for Asset Teams, CDTs, etc.
    • Adopting new technologies to better support functions
    • Providing expertise in MS Project, Project Server, OnePager, and Sharepoint
    • Providing training to functional project management teams
    • Providing a consistent look and feel across all templates and tools to ensure portability across teams 




  • College degree in relevant field of study (required)
  • 10+ years of experience in life sciences and biotechnology industry (required), with experience in managing cross-functional Development or Commercialization teams.
  • 5-7 years experience in life sciences and biotechnology industry asset-level project management with demonstrated knowledge of Project Management tools (e.g. MS Project)
  • Proven ability to both translates strategy and ensure tactical execution of solutions to operational issues in a fast-paced environment
  • Experience having successfully managed projects/programs and business/change initiatives
  • Demonstrated experience in scenario planning, problem resolution and goal setting for teams
  • Demonstrated track record of working collaboratively in a cross functional environment, and leading people without reporting authority
  • Distinctive communication (oral, written, and presentation), analytical, and strategic thinking skills
  • Excellent planning, project management and problem-solving skills
  • Proven skills at negotiating solutions in complex environments





  • Communication – Excellent communication, analytical, scientific assessment, and presentation skills, including ability to communicate succinctly and effectively to key stakeholders
  • Collaboration – Strong collaborative skills to assure alignment of strategic and operational plans across functions and geographies.  Flexible and positive approach.
  • Problem-Solving – Demonstrated ability to troubleshoot on complex issues within a matrix environment.   Driven and results oriented.
  • Credible – Ability to challenge product/project assumptions to resolve conflicts, optimize timelines and cost through sound knowledge of all stages of drug development and commercialization.
  • Resourceful – Demonstrated ability to regularly seek out and incorporate well-informed perspectives, both internally and externally, to develop deeper insights. 
  • Focused – Ability to complete tasks to deadlines and prioritize conflicting demands.  Proactive and detail oriented.
  • Standalone – Ability to work independently and with little formal support to lead projects and motivate teams


Nearest Major Market: Philadelphia