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Process Development Associate

Date: Feb 19, 2021

Location: Philadelphia, PA, US

Company: Spark Therapeutics

Join the Spark Team


We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.


We don’t follow footsteps. We create the path.




The Upstream Process Development Associate is involved in the execution of recombinant adeno-associated viral vector (rAAV) production processes.   The Upstream Process Development Associate executes experiments, develops production procedures and other relevant documentation, and works under supervision.  He/she will be responsible for:

  • Culturing mammalian cells for viral production in shake flasks, spinner flasks, spin tubes and/or benchtop bioreactors.
  • Performing experiments in the development, optimization and scale-up of production processes. 
  • Preparing and reviewing process development protocols, data analysis summaries, technical reports, and other relevant process documentation.
  • Optimization of transfection and transduction protocols
  • Maintaining an accurate laboratory notebook.
  • Ensuring work conforms to applicable quality and safety standards.
  • Participating in the technology transfer from process development to manufacturing sites (as needed).
  • Successful training of colleagues on various experimental assays
  • Participating on project teams (as needed).
  • Other duties as assigned.




70%       Perform laboratory support work and execute laboratory experiments.

10%       Analyze data from experiments and draft presentations.

10%       Draft protocols for studies and the subsequent technical reports as needed.

10%       Attend meetings and perform administrative duties as needed.





  • B.S. in chemical engineering, chemistry, biochemistry, or biology/molecular biology or related area.  Master’s degree preferred.
  • Generally, has 3 – 5 years of relevant scientific or technical experience in the life sciences industry or equivalent. 
  • Experience in cell culture including materials, instruments and technologies is essential.
  • Experience with viral vector production is preferred.  




  • Hands-on experience in cell culture production processes.  This includes small scale (shaker flasks, spinner flasks, spin tubes) and/or benchtop bioreactor scale.
  • Hands-on experience with various Molecular Biology techniques and basic biochemistry (SDS-PAGE, Western blot, qPCR, cloning etc).
  • Working knowledge of state-of-the-art principles, technologies, and instrumentation.
  • Effective communication skills (verbal, written, interpersonal). Must be able to draft protocols and technical reports.
  • Hands-on experience with analytical techniques (IEF, HPLC-FPLC, Octet,) is a plus.
  • Must be able to interact with cross-functional teams. 
  • Analytical and problem-solving skills.
  • Ability to manage time effectively.
  • Ability to communicate and negotiate with vendors in a strategic manner.
  • Ability to work well under pressure and meet deadlines.
  • Proficiency in MS Office, JMP, Phyton and R/RStudio is a plus.

Nearest Major Market: Philadelphia