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Preclinical Lead-Autoimmunity

Date: Jun 11, 2021

Location: Philadelphia, PA, US

Company: Spark Therapeutics

Join the Spark Team

 

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.

 

We don’t follow footsteps. We create the path.

 

Primary Duties

 

Preclinical Lead (Autoimmunity), reporting directly to the Head of Immunology, will be responsible for the proof-of-concept studies design/execution, the choice of autoimmune indications and establishing the candidate development strategy from Research to Preclinical stage. The position will also work cross functionally with the Clinical Development team to prepare for advancement of autoimmune programs into later stages, filings and inspections, establishing clinical endpoints, development protocols, safety reviews and regulatory strategies and interactions. Preclinical Lead (Autoimmunity) will create and lead the Autoimmune Disease research group and promote a strong creative culture with a clear sense of urgency for providing life-changing gene therapies to patients.

 

 

Responsibilities

 

% of Time

Job Function and Description

 

60%

Design and oversee the execution of the proof-of-concept studies

 

20%

Provide scientific leadership and management to the Autoimmune Disease group

 

10%

Design the candidate drug development strategy from Research to Preclinical stage

 

 

5%

Provide scientific and strategic input in the evaluation of new technologies and preclinical development or in-licensing of candidate drugs as well as over-sight of outsourced bioanalytical work to CROs

        

 

         5%

Screen the landscape of autoimmune disease treatment to propose potential novel indications for gene therapy use

 

 

 

Manage [Autoimmune Disease Team in the Research Department] team to achieve business goals and objectives.

  • Foster Spark’s Culture.  Role model the Spark Values. Create an environment where team members thrive by living our truths, always in compliance with applicable laws and regulations. Emphasize to employees that “how” they achieve performance objectives is just as important as “what” they accomplish.
  • Hire & Integrate.  Know what skills, experiences and capabilities are needed to achieve current and future business goals. Take an active role in attracting and selecting talent who are inspired by our Mission, Vision and Values.  Consciously create a team with diverse backgrounds, experiences, skill sets and perspectives.  Help new team members successfully integrate into Spark so they can actively contribute and add value as quickly as possible.
  • Manage performance.   Ensure every team member knows what is expected of them, what it takes to be successful, and how they are progressing.  Provide team members with continuous and on-going performance feedback, holding everyone accountable to achieve results while demonstrating the Spark Values. Help team members understand how their work contributes to the overall success of Spark by continuously communicating priorities, decisions and changes; adjusting goals as needed.
  • Develop people.   Understand each individual team member’s career goals. strengths and motivators.  Partner with your employees to identify areas for development, conduct coaching conversations regularly and provide guidance on ways to develop through on the job experiential learning and stretch opportunities.

 

Education and Experience Requirements

 

  • Ph.D. in Immunology or related field required and at least 8 years of scientific/medical experience in Autoimmunity field
  • 2 years of management experience
  • A strong background in AAV, non-viral gene therapy or vaccination is preferred
  • Track record in the discovery and development of new autoimmune therapies including leading project, teams and contributing to Pre-IND, IND, and other regulatory filings.

 

Key Skills, Abilities, and Competencies

 

  • Able to set strategy and lead research projects by planning, designing, and executing multiple, complex research projects that support corporate scientific goals and priorities.
  • A strong leader as evidenced by internal consulting, mentoring, and project team leadership and active support.
  • Maintain expertise through review of current scientific literature, submissions to scientific journals, and attendance and participation at conferences.
  • Demonstrated excellence in a wide array of scientific techniques and methodologies.
  • Excellent written, verbal, and interpersonal communication skills.
  • Strong publication record

 

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Nearest Major Market: Philadelphia