PreClinical Histopathology Lead- CNS, Ocular
Date: Mar 30, 2021
Location: Philadelphia, PA, US
Company: Spark Therapeutics
Join the Spark Team
We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.
We don’t follow footsteps. We create the path.
Primary Duties |
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This individual will have primary responsibility for designing and executing histopathological studies aiming to evaluate histopathological changes in CNS and ocular tissue after administration of genetic therapies. This individual will, in time, establish a small team dedicated to carrying our histopathological studies and will be responsible for building capacity to evaluate biodistribution of gene therapy vectors in different species. This Lead will also be charged with expanding the organization’s capacity for using imaging technologies (PET, MRI) to evaluate neurodegenerative processes as well as the modulation of those processes after treatment. This position will require deep subject matter expertise, as well as the ability to manage and contribute to diverse cross-functional teams.
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Responsibilities |
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% of Time |
Job Function and Description
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50% |
Analysis of histological specimens |
30% |
Preparation of study reports or otherwise communicating and/or presenting results |
20% |
Management of staff and operations |
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Manage a team to achieve business goals and objectives.
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Education and Experience Requirements |
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The following are desirable but not required:
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Key Skills, Abilities, and Competencies |
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Neuropathology; ability to identify and characterize pathologic changes in the brain of multiple species; deep knowledge of CNS cell types (neurons, astrocytes, microglia etc) and ability to use histological techniques to identify those cells in CNS tissues Ocular pathology; ability to identify and characterize pathologic changes in the eye of multiple species, in particular non-human primates. Familiarity with retinal cell types including RPE, photoreceptors, Muller cells and ganglion cells. Histology; experience in performing and analyzing histological specimens from CNS and ocular tissues of multiple species
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Nearest Major Market: Philadelphia