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PD Downstream Scientist

Date: Jun 10, 2021

Location: Philadelphia, PA, US

Company: Spark Therapeutics

Join the Spark Team


We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.


We don’t follow footsteps. We create the path.



The process development downstream team is seeking a highly motivated and innovative process scientist. The position will primarily a lab-based role, s/he is responsible for developing robust and scalable downstream manufacturing process to support early and late phase gene therapy products in Spark’s innovative pipeline. The role will also be responsible for providing technical support to technology transfer, scale up, and internal/external manufacturing, as well as regulatory filings as needed.



Describe the essential daily job functions and include % of time spent on each.


Job Function and Description


  • Design and execute lab experiment to develop efficient, robust, scalable and cost-effective downstream purification process


  • Analyze and interprets process and analytical data to make sound decisions
  • Maintain accurate and complete lab notebooks. Authoring technical reports, data summaries, tech transfer reports.
  • Present results in internal meetings or external conferences.



  • Interact with internal and external partners, may represent functional area on cross functional teams
  • Support downstream process tech transfer, scale-up, clinical and commercial manufacturing as needed
  • Support regulatory filings
  • Leverage personal strength, knowledge and experience to mentor colleagues or intern student




  • Ph.D. in Chemical/Biochemical Engineering, Biological Sciences, or a related scientific discipline, or MS with 3+ years of relevant industry experience
  • In depth understanding and hand on experience in one or more of the following area is required: preparative chromatography, membrane filtration (NFF, TFF, viral filtration), membrane chromatography, continuous processing, process modeling
  • Experience with high throughput liquid handling and robotics as applied to downstream process development is preferred
  • Knowledge of analytical methods to support product and process characterization is preferred
  • Knowledge of statistical methods for DOE design and data analysis (e.g. JMP) is highly desirable
  • Experience with downstream process development of biological products, such as viral vectors, vaccine, recombinant proteins is preferred





Nearest Major Market: Philadelphia