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Molecular Assay Lead

Date: Apr 20, 2021

Location: Philadelphia, PA, US

Company: Spark Therapeutics

Join the Spark Team

 

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.

 

We don’t follow footsteps. We create the path.

 

Primary Duties

 

 

The Molecular Assay Lead will be a member of the Bioanalytics department, overseeing multiple non-clinical and clinical assays for advancing fast-paced novel gene therapy programs across all Therapeutic Areas. The position requires expert knowledge in molecular bioanalytical and biomarker assay development, including gene copy number, biodistribution and vector shedding, preclinical and clinical sample testing, data analysis and technical troubleshooting.

 

Responsibilities and expectations include:

  • Manage the development of multiple molecular analytical assays and preclinical and clinical sample testing efforts simultaneously while directing team members on technical work and interfacing with the therapeutic program leads, ensuring assay requirements are fulfilled within strict timelines.
  • Apply strong molecular biology and bioanalytical knowledge for developing nucleic acid-based assays to support the preclinical and clinical activities.
  • Lead experimental design, data analysis and review, prepare results documentations.
  • Utilize high level of technical expertise and sound judgment for troubleshooting complex molecular biology technical problems and finding appropriate solutions.
  • Expertise in DNA, RNA, miRNA assays, including DNA/RNA isolation and primer design.
  • Proficient with qRT-PCR, qPCR, and dPCR methods and skilled in trouble-shooting technical issues.
  • Experience with high-throughput processing devices such as QuantStudio, QIAsymphony and KingFisher to accommodate large number of sample testing.
  • Support implementation and utilization of LIMS and Sample Management systems for preclinical assays and tracking sample inventory.

 

 

Responsibilities

 

% of Time

Job Function and Description

40%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Manage team members and support the Bioanalytics function to achieve business goals and objectives.

 

  • Foster Spark’s Culture.  Role model the Spark Values. Create an environment where team members thrive by living our truths, always in compliance with applicable laws and regulations. Emphasize to employees that “how” they achieve performance objectives is just as important as “what” they accomplish.
  • Hire & Integrate.  Know what skills, experiences and capabilities are needed to achieve current and future business goals. Take an active role in attracting and selecting talent who are inspired by our Mission, Vision and Values.  Consciously create a team with diverse backgrounds, experiences, skill sets and perspectives.  Help new team members successfully integrate into Spark so they can actively contribute and add value as quickly as possible.
  • Manage performance.   Ensure every team member knows what is expected of them, what it takes to be successful, and how they are progressing.  Provide team members with continuous and on-going performance feedback, holding everyone accountable to achieve results while demonstrating the Spark Values. Help team members understand how their work contributes to the overall success of Spark by continuously communicating priorities, decisions and changes; adjusting goals as needed.
  • Develop people.   Understand each individual team member’s career goals, strengths and motivators.  Partner with employees to identify areas for development, conduct coaching conversations regularly and provide guidance on ways to develop through on the job experiential learning and stretch opportunities.

 

20%

 

Lab related activities, including running experiments, data reviews, and participating in process and technology improvement.

 

20%

Process and technology improvement for increased efficiency and higher capacity

 

20%

Assist with workflow and manage shifting priorities

 

Education and Experience Requirements

  • Ph.D. in a relevant field required.
  • 5+ years molecular assay related experience
  • Strong knowledge in molecular assay development in biological matrices, data analysis and technical troubleshooting to find suitable solutions.
  • Extensive experience with biological sample testing, analyzing data and summarizing results in technical documents.
  • Extensive experience using analytical tools such as SoftMax Pro, Prism and Excel.
  • Experience with personnel management and workflow coordination.
  • Knowledge of GLP and regulatory expectations
  • Experience with gene therapy desired.

 

Key Skills, Abilities, and Competencies

 

  • People management and work coordination skills are crucial.
  • Excellent organizational and multi-tasking skills are required.
  • Excellent interpersonal, writing and verbal communication skills are required.

 

#LI-JW1

 


Nearest Major Market: Philadelphia