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Manufacturing Science and Technology Upstream Process Scientist/Engineer

Date: Nov 26, 2020

Location: Philadelphia, PA, US

Company: Spark Therapeutics

Join the Spark Team

 

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.

 

We don’t follow footsteps. We create the path.

 

Summary

 

The Manufacturing Science and Technology (MST) Upstream Process Scientist/Engineer is an entry-level position within the MST Lab team, which is responsible for carrying out laboratory experiments to support clinical and commercial manufacturing of gene therapy products and late-stage process development activities.  To support manufacturing, the incumbent will develop an understanding of Spark manufacturing processes in order to assist in the evaluation of raw materials and equipment, investigation of process deviations and development of process improvements.  Late-stage process development activities, such as process characterization, will require the incumbent to build an understanding of new processes in the clinical pipeline delivered from the Process Development organization, with whom the incumbent will interact with regularly.

 

The incumbent’s major responsibility in the activities described above is hands-on execution of laboratory experiments for upstream bioprocessing, such as cell culture in flasks and bioreactors.  The experimental scope spans experimental design, in-lab execution, documentation of results using Good Documentation Practices and data analysis.

 

In addition to the development responsibilities described above, the incumbent will also take part in the tech transfer of production processes into clinical and commercial manufacturing suites through interaction with the Process Development organization and both internal and external manufacturing partners.  Lastly, the incumbent will take part in the design and implementation of new manufacturing areas within Spark.

 

Responsibilities

80%        Working in the lab to perform experiments while synchronously documenting work in electronic laboratory notebooks.

10%        Contributing to new manufacturing suite design and preparing documentation for equipment requirements, purchase, installation and qualification.

10%        Contributing to process development reports and tech transfer documents

 

 

Qualifications

•           BS in biochemistry or engineering (either chemical, biochemical, or bio), or related area, with 0-2 years of relevant experience.

•           Knowledge of upstream bioprocessing and relevant cell biology and biochemistry concepts.

•           Hands-on general laboratory or manufacturing experience in either an academic or industrial setting.

•           Hands-on experience with growing cells in flasks and bioreactors is a plus.

 

Key Skills, Abilities, and Competencies

•          Strong organizational skills and detailed documentation abilities are required.

•          Ability to perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies. 

•          Excellent writing and verbal communication skills is required.

•          Teamwork is a must.

•          Must be comfortable in the fast-paced, multi-tasking biotech environment.

•          On a regular basis, the Upstream Process Scientist/Engineer needs to work closely with senior lab members to execute various experiments, including complex and large-scale processes.

•          Strong data organization skills, interpretation and troubleshooting are critical to be successful.

•          Execute various tasks in a highly accurate manner and deliver the data on time.

•          The Upstream Process Scientist/Engineer needs to contact external experts, including vendors and consultants, to  evaluate new technologies, equipment, and materials    

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Nearest Major Market: Philadelphia