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Enterprise Architecture Lead, Manufacturing

Date: Jun 10, 2021

Location: Philadelphia, PA, US

Company: Spark Therapeutics

Join the Spark Team


We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.


We don’t follow footsteps. We create the path.





The Enterprise Architect, Manufacturing, enables business and IT leaders to make investment decisions that balance and prioritize current operational demands, disruptions, and opportunities with the longer-term strategic vision of the Spark Technical Development and Operations organization.   The Enterprise Architect develops Business and Information Architecture models, provides technology guidance, and collaborates on road maps, principles, and standards. 


The Enterprise Architect clarifies strategic intentions, identifies desired business outcomes, and explores implications, impacts, and risks. They create deliverables for business leaders that support organizational change and investments in response to disruptive forces and toward achieving targeted business outcomes. They facilitate discussion with key business stakeholders around technology, business capabilities, value-streams and processes and other key enterprise architecture deliverables. They work to develop an integrated view of the enterprise using a repeatable approach, cohesive framework, and available industry standard techniques.


Business Solution Architecture


  • Provides guidance and definition to effectively align the Biopharmaceutical Technical Development and Manufacturing business strategy to IT architecture.
  • Works with business counterparts to evaluate capabilities that enable business outcomes, identify gaps and opportunities, and develop roadmaps and recommendations against the current portfolio of solutions to best enable the business strategy.
  • Defines, explains, and advocates technology strategy to business counterparts.
  • Provides strategic consultation to business and IT leaders.
  • Works with business leaders to understand business requirements and help them understand how technology tradeoffs influence strategy.
  • Ensures recommendations are based on business relevance, appropriate timing, and deployment
  • Reviews existing business processes and establishes metrics to improve business processes.
  • Pursues and build relationship across business and IT to gather intelligence and bring insight about the wider picture 


Information Architecture


  • Reviews and/or analyzes and develops architectural requirements as needed for the TD&O organization.
  • Advises on options, risks, costs versus benefits, system impacts, and technology priorities.
  • Works on highly complex projects that require in-depth knowledge across multiple specialized architecture domains.
  • Collaborates with project management and IT leaders to ensure progress towards architectural alignment with project goals and requirements.
  • Manages exceptions to architectural standards for the TD&O Org.
  • Ensures the conceptual completeness of the technical solutions.
  • Works with senior leadership to approve allocation of budget to meet architectural initiatives critical to business/mission success.
  • Collaborates with SMEs and Data Architecture to model the data flow for the Manufacturing organization, from source to target – ensuring seamless information flow across end-to-end processes
  • Work with functional leads to define business information needs and assess the implications to the information architecture


Enterprise Architecture Governance and Content Management


  • Contributes to the development and communication of architectural policies, standards, guidelines, and procedures.
  • Supports all architectural disciplines and champions architectural initiatives.
  • Facilitates review of solutions for the TD&O Org with the EA review board and ensures that the solutions are compliant with target-state architecture models.
  • Participates in the creation of governing principles to guide EA decision making.
  • Accountable for the long-term fit of the architectures for several domains, maintain domain knowledge and define the domain maintenance plan 



  • Analyze emerging technology, market trends and their potential impacts on the domain architecture
  • Contribute to building a pipeline of innovation candidates by evaluating industry trends and opportunities against Spark's strategic goals and imperatives
  • Keep knowledge up to date with respect to state-of-the-art technology, equipment, systems, and processes relevant to Biopharmaceutical Technical Development and Manufacturing.


Education and Experience Requirements

  • Bachelor’s Degree in business, information systems, industrial engineering or a related field, and extensive relevant project experience
  • 10 Years of IT and business/industry work experience including architecture design and deployment, business analysis, systems lifecycle management, and program management.
  • Leadership experience in managing multiple, large, cross-functional teams or projects, and influencing senior level management and key stakeholders.
  • Requires exposure to multiple, diverse technologies and processing environments.
  • Knowledge of all components of holistic enterprise architecture, business re-engineering principles and processes.  Knowledge of architecture framework and methods, such as TOGAF.  TOGAF Level 2 Certification a plus.
  • Experience in one or more of the following areas in a Life Science Biopharma Manufacturing environment: business transformation and optimization, strategic planning, leadership, business relationship management and business process management.


Key Skills Abilities and Competencies


  • Deep knowledge and experience in Life Science Biopharma information management trends and leading practices across the full Life Science value chain
  • Knowledge of existing, new, and emerging technologies and ability to practically apply them to new business designs and business models to achieve targeted business outcomes.
  • Ability to model business capabilities, value streams, business processes, and organizational structures in alignment with business stakeholders and SMEs.
  • Comprehensive knowledge of organization change management concepts.
  • Strong analytical and conceptual skills; ability to create original concepts and theories for a variety of projects
  • Ability to communicate, influence and persuade — both business and IT leaders, as well as peers.
  • Uses the language of business leaders and join the conversation that's taking place.
  • Ability to adapt to rapidly changing technologies and see how they can support business needs.
  • Ability to establish and maintain a high level of stakeholder trust and confidence.
  • Understands business process management, workflow and integration methods and tools
  • Deep knowledge and experience in Information Management and Architecture Design - ability to use appropriate tools and logical models to develop an information architecture to meet company needs​
  • Communicate effectively with both technical and business individuals at all levels – strong ability to translate information management concepts to business stakeholders in business terms


Complexity and Problem Solving


  • Provides strategic leadership to ensure that the IT strategy aligns with business priorities​
  • Undertakes objective, critical analysis to work through issues, explore different possibilities, and identify the most effective solution that takes account of business context​
  • Influences the organization, users, or vendors on architecture decisions
  • Monitors the market to gain knowledge of new and emerging technologies and assess the relevance and potential value to the company​
  • Analyzes project needs and determines resources needed to meet objectives and solve problem


Nearest Major Market: Philadelphia