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Analytical Development Scientist

Date: Feb 14, 2021

Location: Philadelphia, PA, US

Company: Spark Therapeutics

Join the Spark Team

 

We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now.

 

We don’t follow footsteps. We create the path.

We are seeking a scientist who will be responsible for developing, optimizing, and running our Mass Spectrometry workflows in Analytical Development.  This scientist will play a key role in designing and executing MS methods for viral vector-based therapies.  S/he will collaborate with other scientists to implement MS methods for AAV gene therapy product characterization and optimization of AAV platforms.

 

The scientist will:

  • Develop and/or optimize protein identification (host-cell protein, intact mass, peptide mapping) workflows for product characterization
  • Conduct experiments to support process development and platform development
  • Be responsible for timely execution of experiments and interpretation of data
  • Keep accurate, clear, and updated notebooks and records
  • Help to maintain and troubleshoot MS and related equipment
  • Provide input on design of new assays in Analytical Development and help to troubleshoot experiments
  • Author and review technical reports and SOPs
  • Collaborate with others within Process and Technology Development to support the pipeline

 

Responsibilities

50%        Working in the lab to execute experiments and troubleshooting experiments/equipment

35%        Design experiments, maintain notebooks, discuss and interpret data

10%        Preparation of presentations for group meetings

5%          Mandatory trainings and group meetings

 

Education and Experience Requirements

PhD in a relevant scientific discipline such as biological sciences, biochemistry, or analytical chemistry.  Post-doctoral research or 1-2 years relevant biotech or pharmaceutical company experience preferred but not required.  Or Bachelor’s or Master’s degree in a relevant scientific discipline with 3-5 years of related experience within an established biotech or pharmaceutical company.

 

Key Skills, Abilities, and Competencies

  • Demonstrated hands-on experience with developing and using established and emerging MS technologies (e.g. IMS-Q-TOF, Orbitrap, etc…) and different applications (e.g., Mascot,  MaxEnt, BioConfirm etc.)
  • Track record of assessing and implementing novel strategies to optimize protein identification and characterization workflows
  • Familiarity with bioinformatic tools and track record of collaborating with bioinformatics scientists
  • In-depth understanding and knowledge of MS applications to complement the hands-on experience
  • Experience with development of investigational products
  • Ability to work independently and assume ownership of experiments to drive results with minimal supervision
  • Strong analytical and problem-solving skills needed in order to design assays and experiments to answer complex analytical challenges
  • Must be able to work in a collaborative manner in a team-based environment
  • May provide guidance to more junior team members
  • Familiarity with Distiller, Percolator, R is a plus.

Complexity and Problem Solving

  • Must be able to design solutions to complex analytical problems
  • Plans, schedules, and arranges own activities to meet objectives
  • Demonstrates good judgement in selecting methods/techniques for desired outcome
  • Advanced skills in interpreting and synthesizing data and effectively communicating findings with some coaching from senior team members
  • May refer to established procedures and guidelines

Internal and External Contacts

  • May represent department as a prime contact on contracts or projects
  • Interacts with senior internal/external personnel on significate matters often requiring coordination between organizations/departments/teams
  • Interfaces with senior internal/external personnel in own area of expertise

 

 

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Nearest Major Market: Philadelphia